Fig. 3 | International Journal of Oral Science

Fig. 3

From: Integrative single-cell and bulk transcriptomes analyses reveals heterogeneity of serine-glycine-one-carbon metabolism with distinct prognoses and therapeutic vulnerabilities in HNSCC

Fig. 3

High SGOC metabolism shows an aggressive phenotype. UMAP plots of malignant cells colored by cell type (a) and patient origin (b). c The hierarchical clustering of the malignant clusters colored by patient origin. d UMAP plots of malignant cells colored by SGOC cores. e Dot-plots shows the expressions of SGOC metabolic network, EMT and cell cycle. f Spearman correlation analysis of the expressions of SGOC metabolic network and cell cycle. g KEGG analysis of the pathway enrichment of feature genes of malignant cell clusters. h The cumulative cell proportion of the malignant cell clusters is shown in TCGA-HNSCC. i Univariate Cox analysis of the correlations between malignant cell clusters and overall survival of HNSCC patients in TCGA-HNSC cohort. j Kaplan–Meier curves of overall survival (OS) according to malignant cell clusters in TCGA-HNSC cohort. *P < 0.05

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