Fig. 4 | International Journal of Oral Science

Fig. 4

From: Integrative single-cell and bulk transcriptomes analyses reveals heterogeneity of serine-glycine-one-carbon metabolism with distinct prognoses and therapeutic vulnerabilities in HNSCC

Fig. 4

Developing a four-gene SGOC signature for prognostication in HNSCC patients. a Venn diagram of differentially expressed SGOC-associated genes between malignant cells and non-malignant cells. b Univariate Cox analysis of the correlations between SGOC-associated genes and overall survival of HNSCC patients in TCGA-HNSC cohort. c Heatmap of differentially expressed SGOC-associated genes between malignant cells and non-malignant cells. d, e Kaplan–Meier curves for the OS (d) and disease-free survival (DFS) (e) of high- and low-risk groups in the TCGA-HNSC cohort. f Kaplan–Meier curves for the OS of high- and low-risk groups in the GSE41613, GSE65858 and GSE42743 cohorts. g Kaplan–Meier curves for the OS of high and low-risk groups in patients treated with chemotherapy in TCGA-HNSC cohort. h Violin diagram showed the differences of SGOC scores between high- and low-risk patients. i Spearman correlation analysis of the SGOC risk scores and cell cycle scores. j Dot-plot shows the expressions of hallmark signaling of high- and low-risk patients. *P < 0.05

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