Fig. 6 | International Journal of Oral Science

Fig. 6

From: Mandible-derived extracellular vesicles regulate early tooth development in miniature swine via targeting KDM2B

Fig. 6

Mandible-EVs transferred miR-206 to regulate cell proliferation and differentiation of dental mesenchymal cells. a The mRNA level of KDM2B in dental mesenchymal cells treated by KDM2B or miR-206/KDM2B. b The level of miR-206 in dental mesenchymal cells treated by KDM2B or miR-206/KDM2B. c EdU assays were applied to confirm the proliferation ability of dental mesenchymal cells regulated by miR-206/KDM2B. Scale bar: 200 μm. d Quantitative analysis. e The mRNA level of DSPP regulated by miR-206/KDM2B. f The mRNA level of DMP1 regulated by miR-206/KDM2B. g The protein level of DSPP and DMP1 regulated by miR-206/ KDM2B. h, i Western blotting quantification. n.s not significant, * P < 0.05, ** P < 0.01

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