Fig. 1 | International Journal of Oral Science

Fig. 1

From: NUP62 alleviates senescence and promotes the stemness of human dental pulp stem cells via NSD2-dependent epigenetic reprogramming

Fig. 1

NUP62 mRNA and protein levels are decreased in aged human dental pulp stem cells (HDPSCs). a Heatmap of signature proteins that were differentially expressed in HDPSCs isolated from different donors (>1.5-fold, t test, p < 0.05). b, c Immunofluorescence staining of γH2AX and quantification of fluorescence intensity (n = 5). Scale bar, 50 μm. d Heatmap of Nups expression in HDPSCs isolated from different donors (> 1.5-fold, t test, p < 0.05). e Boxplot of NUP62 levels in HDPSCs isolated from different donors. f, g Western blot analyses of NUP62 and P21 expression with age. h, i Immunofluorescence staining of NUP62 and quantification of fluorescence intensity (n = 5). Scale bar, 50 μm. **P < 0.01 and ***P < 0.001

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