Fig. 2 | International Journal of Oral Science

Fig. 2

From: Lysine-specific demethylase 1 controls key OSCC preneoplasia inducer STAT3 through CDK7 phosphorylation during oncogenic progression and immunosuppression

Fig. 2

STAT3 inhibition by SP2509 reduced cell cycle progression and promotes immune response. a Fold change of Kdm1a, Stat3, and Ctla4 mRNA expression after treatment with SP2509 in mice OSCC preneoplasia. b Altered STAT3 protein expression in HSC3 compared to normal epithelial cells, and KDM1A knockout. c Gene set enrichment analysis (gene ontology) shows reduction in cell division and elevation in immune response when treated with SP2509. d Validation of G0/G1 cell cycle arrest after SP2509 and sgKDM1A treatment to HSC3 cells. Statistical analyses were performed using a t-test and one-way ANOVA. “ns” P > 0.05, *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.000 1

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