Fig. 3 | International Journal of Oral Science

Fig. 3

From: Lysine-specific demethylase 1 controls key OSCC preneoplasia inducer STAT3 through CDK7 phosphorylation during oncogenic progression and immunosuppression

Fig. 3

SP2509 has a unique mechanism to promote infiltration of CD8+ T cells in tongue OSCC and inhibiting immunosuppressive CTLA4+ CD25+ T cells: LSD1 regulates tumor immune microenvironment and inhibition with SP2509 facilitates infiltration of various immune cell types: a SP2509 promotes infiltration of CD45+, TCRβ+, CD4+, and CD8+ T cells, and b Reduces CTLA4+ CD25+ (of CD4+ T cells) immunosuppressive cells in OSCC. c Secreted cytokines measured from serum samples showing a significant increase in proinflammatory cytokines like IFNβ, IFNγ, and IL9 in the SP2509 treatment group. “ns” P > 0.05, *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.000 1

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