Fig. 3 | International Journal of Oral Science

Fig. 3

From: Osteomodulin modulates the inflammatory responses via the interleukin-1 receptor 1/nuclear factor-κB signaling pathway in dental pulpitis

Fig. 3

OMD suppressed the NLRP3 inflammasome activation of hDPSCs induced by LPS/ATP. a–c RT-qPCR assay showing the changes in the levels of NLRP3 inflammasome-related factors such as NLRP3, IL-1β, and Caspase-1 in hDPSCs stimulated by combined administration of 1 µg/mL of LPS and 0.5–1.0 µg/mL of rhOMD for 6 h followed by the treatment with 1 mM ATP for another 30 min. d WB assay results of NLRP3, pro-caspase-1, cleaved-caspase-1, pro-IL-1β, and cleaved-IL-1β. e Quantitative analysis of the protein expression in (d). The results are expressed as mean ± SD (*P < 0.05, **P < 0.01, and ****P < 0.000 1; ns means no significance)

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