Fig. 4 | International Journal of Oral Science

Fig. 4

From: Osteomodulin modulates the inflammatory responses via the interleukin-1 receptor 1/nuclear factor-κB signaling pathway in dental pulpitis

Fig. 4

OMD inactivation accelerated the inflammatory response in LPS-induced hDPSCs and LPS-treated mice pulp tissues. a, b The mRNA expression of TNFα and IL-1β in siOMD hDPSCs treated with 1 μg/mL of rhOMD alone, 1 μg/mL of LPS alone, or combined 1 μg/mL of LPS and 1 μg/mL of rhOMD for 24 h. c Graphical illustration of the construction of the pulpal inflammatory mouse model and a representative occlusal view of the surgical processes, with a red arrow indicating the exposed pulp chamber treated with either LPS alone or a combination of LPS and rmOMD then sealed. d, e HE and immunofluorescence staining of TNFα and IL-1β, with ×5 magnification (scale bar: 500 μm) and ×20magnification (scale bar: 100 μm). Results are expressed as mean ± SD (****P < 0.000 1)

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