Fig. 4

Integration of sci-RNA-seq and bulk RNA-seq reveals cell-specific lncRNAs in developing fetal teeth. a UMAP visualization of nine clusters integrated from previously published sci-RNA-seq datasets of developing fetal teeth at the cap stage (9–11 and 12–13 gw) and early bell stage (14–16 gw).³⁸ DE and DM clusters annotated with KRT14 and MSX1. b Dot plots of highly expressed lncRNAs in DE (red) and DM (blue) from sci-RNA-seq. Feature plot highlighting high expression of PANCR and MIR205HG in DE, and FGF10-AS1 and DLX6-AS1 in DM. c Volcano plot of differentially expressed lncRNAs in DE and DM identified by bulk RNA-seq. d Venn diagrams and heatmap of up-regulated lncRNAs in DE and DM showing overlap between bulk RNA-seq and sci-RNA-seq