Fig. 6
From: Profiling and functional characterization of long noncoding RNAs during human tooth development
CDP-specific DLX6-AS1 enhances odontoblastic differentiation of hTGMCs and hDPSCs. a UMAP plot of six clusters from previously published sci-RNA-seq datasets of developing fetal teeth at the late bell stage (17–19 and 20–22 gw).38 b UMAP plot of DP marker FGF3, odontoblast marker DSPP, and lncRNA DLX6-AS1. RNAscope ISH staining of DLX6-AS1 in human fetal molars at 17 gw. Scale bar, 100 μm. ALP staining after 7-day odontogenic induction in hTGMCs (c) and hDPSCs (d) with DLX6-AS1 knockdown. Relative expression of DLX6-AS1, DSPP, SP7, and ALPL after 7-day odontogenic induction in hTGMCs (e) and hDPSCs (f) with DLX6-AS1 knockdown was measured by qRT-PCR
