Fig. 10 | International Journal of Oral Science

Fig. 10

From: LncRNA EUDAL shapes tumor cell response to hypoxia-induced constitutive EGFR activation and promotes chemoresistance in oral cancer

Fig. 10

EUDAL/EGFR/STAT3/autophagy signal axis reflects the efficacy of chemotherapy in patients with oral cancer. a Left: Representative CT scans in patients having a good response or a poor response before and after receiving platinum-based chemotherapy. Right: Representative immunohistochemistry staining for pEGFR, pSTAT3, and LC3B, and RNA FISH staining for EUDAL in tumor tissues from patients with a good or a poor response to Platinum-based chemotherapy. b Semi-quantitative analysis showed lower EUDAL, pEGFR, pSTAT3, and LC3B levels in good responders than in poor responders. Error bars: mean with interquartile range. c Correlations among EUDAL, pEGFR, pSTAT3, and LC3B levels in tumor tissues. d A proposal schematic model illustrating that a novel lncRNA EUDAL facilitates the hypoxia-induced noncanonical phosphorylation of wild-type EGFR and drug resistance by competitively binding to EGFR with c-Cbl and Grb2. n = 45. ****P < 0.000 1; Mann–Whitney U test (b), Spearman rank correlation (c)

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