Fig. 7 | International Journal of Oral Science

Fig. 7

From: LncRNA EUDAL shapes tumor cell response to hypoxia-induced constitutive EGFR activation and promotes chemoresistance in oral cancer

Fig. 7

Hypoxia/EUDAL/STAT3 axis activation results in elevated autophagic flux in tumor cells with originally lower pEGFR levels. a Expression analysis of autophagy-related markers LC3B and p62, as well as pSTAT3 and BNIP3, in HN4 cells following indicated treatments. b Upper: LC3B puncta (white arrowed) identified by fluorescence microscopy in HN4 cells following the indicated treatments. Bar for fluorescent microscopies, 10 μm. Lower: Examination of autophagosome (red arrowed) in HN4 cells following indicated treatments by transmission electron microscopy. Bar for electronic microscopies, 1 μm. Data were from representative results of at least three independent experiments. wt wild-type; EUDAL Del-mut, a lncRNA mutant with an EGFR-binding motif deletion (Δ254–305 nt); KD knockdown

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