Table 3 Linear regression results for anti-S antibody AUC at visit 3 and visit 4 for both PFOA (top) and PFOS (bottom).

From: Immune response to COVID-19 vaccination in a population with a history of elevated exposure to per- and polyfluoroalkyl substances (PFAS) through drinking water

 

Anti-S antibody AUC at visit 3

Anti-S antibody AUC at visit 4

 

Percent change (95% CI)

P value

Percent change (95% CI)

P value

PFOA concentration

14.9 (−8.9, 38.7)

0.22

4.6 (−13, 22.1)

0.61

Age

−2.7 (−4.5, −0.9)

<0.01

−3.1 (−4.4, −1.8)

<0.01

Female vs. male

−20.3 (−56.6, 46.2)

0.46

13.7 (−27.9, 79.2)

0.58

Geographical site: 2 vs. 1

−21.1 (−63.2, 69.2)

0.54

−4.4 (−44.9, 65.7)

0.87

History of COVID-19 (naive vs. recovered)

92.9 (3.5, 259.6)

0.04

21.8 (−22.8, 92.1)

0.4

Vaccine Brand (Moderna vs. Pfizer-BioNTech)

−22.5 (−67.3, 83.4)

0.56

−26.3 (−58.1, 29.5)

0.29

PFOS concentration

5.8 (−21.6, 33.3)

0.68

8.5 (−12.4, 29.4)

0.43

Age

−2.7 (−4.5, −0.9)

<0.01

−3.2 (−4.4, −1.9)

<0.01

Female vs. Male

−22.4 (−57. 9, 43.3)

0.42

15 (−27.1, 81.3)

0.55

Geographical site: 2 vs. 1

−37.1 (−67.9, 23.1)

0.18

−5.4 (−41.5, 52.9)

0.82

History of COVID-19 (naive vs. recovered)

94.1 (3.7, 263.3)

0.04

22.1 (−22.6, 92.6)

0.39

Vaccine Brand (Moderna vs. Pfizer-BioNTech)

−16.5 (−64.8, 98)

0.68

−27 (−58.4, 28.3)

0.28

  1. AUC area under the curve, CI confidence interval, PFOA perfluorooctanoic acid (top), PFOS perfluorooctanesulfonic acid (bottom).