Table 3 Odds ratios (ORs) and 95% confidence intervals (CIs) for cumulative exposure to mononuclear aromatic hydrocarbons, benzene, toluene and xylene and risk of bladder cancer.

From: Occupational exposure to organic solvents and risk of bladder cancer

 

No lag

Lagged 20-Years

 

Cases

Controls

ORsa (95%CI)

Cases

Controls

ORsa (95%CI)

Mononuclear aromatic hydrocarbons

  None

36

74

Ref

69

124

Ref

  Q1

89

93

1.83 (1.08, 3.12)

92

94

1.64 (1.04, 2.58)

  Q2

89

92

1.78 (1.05, 3.03)

89

87

1.80 (1.14, 2.85)

  Q3

107

92

2.17 (1.28, 3.67)

97

91

1.86 (1.18, 2.93)

  Q4

83

92

1.60 (0.94, 2.72)

60

65

1.57 (0.95, 2.60)

   p-trend

 

0.88

  

0.48

Benzene

  None

115

189

Ref

152

239

Ref

  Q1

39

35

1.72 (0.99, 2.99)

35

30

1.71 (0.97, 3.02)

  Q2

33

37

1.44 (0.83, 2.51)

24

32

1.28 (0.70, 2.33)

  Q3

43

33

1.99 (1.15, 3.43)

44

33

2.07 (1.22, 3.53)

  Q4

31

34

1.40 (0.79, 2.48)

26

28

1.38 (0.75, 2.54)

   p-trend

 

0.25

  

0.14

Toluene

  None

86

139

Ref

133

220

Ref

  Q1

16

24

0.98 (0.47, 2.05)

18

28

0.97 (0.49, 1.90)

  Q2

32

24

2.35 (1.24, 4.45)

36

22

2.91 (1.57, 5.39)

  Q3

27

24

1.51 (0.79, 2.90)

23

24

1.47 (0.77, 2.81)

  Q4

26

24

1.62 (0.84, 3.13)

16

17

1.45 (0.67, 3.12)

   p-trend

 

0.15

  

0.25

Xylene

  None

128

220

Ref

169

280

Ref

  Q1

17

22

1.21 (0.59, 2.50)

19

21

1.36 (0.68, 2.74)

  Q2

32

22

2.40 (1.28, 4.50)

35

24

2.37 (1.30, 4.31)

  Q3

19

22

1.43 (0.72, 2.86)

15

22

1.07 (0.52, 2.20)

  Q4

26

21

1.65 (0.86, 3.18)

17

14

1.63 (0.75, 3.58)

   p-trend

 

0.11

  

0.18

  1. aAdjusted for age, smoking status, state, race, ethnicity (Hispanic) and non-solvent exposed high-risk occupations for bladder cancer.