Table 4 Odds ratios (ORs) and 95% confidence intervals (CIs) for ever exposure and cumulative exposure to combined benzene, toluene and xylene (BTX) exposure from job-exposure matrix (CANJEM-based BTX metrics) and with additional expert review (hybrid BTX metrics) and risk of bladder cancer.
From: Occupational exposure to organic solvents and risk of bladder cancer
CANJEM-based BTX metrics | Hybrid BTX metrics | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No lag | Lagged 20-Years | No lag | Lagged 20-Years | ||||||||||
Ca | Co | ORsa (95%CI) | Ca | Co | ORsa (95%CI) | Ca | Co | ORsa (95%CI) | Ca | Co | ORsa (95%CI) | ||
Ever exposed | |||||||||||||
None | 68 | 121 | Ref | 112 | 188 | Ref | 87 | 156 | Ref | 126 | 224 | Ref | |
Uncertain | 939 | 1118 | 1.44 (1.03, 2.01) | 915 | 1071 | 1.44 (1.09, 1.90) | 802 | 931 | 1.47 (1.09, 1.99) | 785 | 889 | 1.53 (1.18, 1.99) | |
Exposed | 175 | 169 | 1.83 (1.23, 2.71) | 155 | 149 | 1.78 (1.25, 2.54) | 293 | 321 | 1.61 (1.15, 2.26) | 271 | 295 | 1.63 (1.20, 2.21) | |
Cumulative exposure | |||||||||||||
None | 68 | 121 | Ref | 112 | 188 | Ref | 87 | 156 | Ref | 126 | 224 | Ref | |
Q1 | 42 | 43 | 1.67 (0.96, 2.93) | 40 | 41 | 1.54 (0.90, 2.63) | 70 | 103 | 1.18 (0.76, 1.83) | 71 | 97 | 1.26 (0.83, 1.90) | |
Q2 | 37 | 42 | 1.68 (0.96, 2.96) | 32 | 38 | 1.66 (0.95, 2.90) | 70 | 85 | 1.48 (0.95, 2.31) | 68 | 82 | 1.52 (1.00, 2.31) | |
Q3 | 47 | 42 | 1.99 (1.15, 3.43) | 44 | 38 | 1.94 (1.14, 3.30) | 81 | 72 | 1.94 (1.25, 3.02) | 80 | 76 | 1.88 (1.24, 2.85) | |
Q4 | 49 | 42 | 1.95 (1.14, 3.36) | 39 | 32 | 2.03 (1.16, 3.57) | 72 | 61 | 2.08 (1.31, 3.31) | 52 | 40 | 2.23 (1.35, 3.69) | |
p-trend | 0.06 | 0.02 | 0.0014 | 0.0010 | |||||||||
