Table 2 Differences in evidence found between the 2011 and 2019 NICE guideline systematic reviews.

From: Options for the diagnosis of high blood pressure in primary care: a systematic review and economic model

 

2011 Review [1]

2011 Review (sensitivity analysis) [1]

2019 Review [4]

Total included studies

20

3

13

Studies included in Home BP meta-analysis (at threshold of 135/85 mmHg)a

3 studies [6, 12, 13]

N = 561

Sensitivity analysis not conducted (mean blood pressure of all 3 studies above normotensive threshold)

4 studies [12, 14,15,16]

N = 963

Studies included in Clinic BP meta-analysis (at threshold of 140/90 mmHg)a

7 studies [7,8,9,10, 13, 17, 18]

N = 3693

3 studies [7, 13, 17]

N = 809

3 studies [17, 19, 20]

N = 1250

  1. aWhile both reviews searched for evidence at various diagnostic thresholds, most evidence was available for the internationally accepted thresholds of 135/85 mmHg for Home BP and 140/90 mmHg Clinic BP; this data was thus most appropriate for meta-analysis.
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