Table 4 Overall and sex-stratified analysis of rs4293393 association with TUG, frailty and morbidity index outcomes at follow-up (cross-sectional analysis).

From: Longitudinal effects of a common UMOD variant on kidney function, blood pressure, cognitive and physical function in older women and men

Phenotype

UMOD rs4293393

 

AG

GG

TUG ≥ 10 s

OR [95% CI], P

  Overall

1.32 [0.93–1.89], P = 0.102

1.00[0.46–2.20], P = 0.988

  Women

1.10 [0.68–1.77], P = 0.708

1.40 [0.47–4.11], P = 0.544

  Men

0.50 [0.29–0.85], P = 0.011

0.70 [0.22–2.23]; P = 0.545

Prefrail/frail

OR [95% CI], P

  Overall

1.20 [0.91–1.59], P = 0.174

1.18 [0.61–2.27], P = 0.620

  Women

0.85 [0.58–1.24], P = 0.386

1.84 [0.69–4.93], P = 0.222

  Men

0.81[0.55–1.21, P = 0.299

0.77 [0.30–1.95], P = 0.580

Morbidity index ≥ 1

OR [95% CI], P

  Overall

1.01 [0.75–1.37], P = 0.940

0.96 [0.47–1.96], P = 0.919

  Women

1.24 [0.81–1.89], P = 0.325

0.82 [0.31–2.16], P = 0.692

  Men

0.78 [0.51–1.21], P = 0.271

1.16 [0.39–3.46], P = 0.786

  1. Data were analyzed by binary logistic regression and are given as odds ratios (OR) with 95% confidence intervals in brackets adjusted for sex in the overall analysis. In logistic regression models for TUG ≥ 10 s, for being prefrail or frail and for morbidity index ≥ 1, genotype was added as fixed factor and AA genotype was set as reference group.
  2. P values < 0.05 were marked in bold.
  3. For the interaction effect between sex and genotype for TUG ≥ 10 s, P = 0.086; for being prefrail or frail, P = 0.467 and for morbidity index ≥ 1, P = 0.257.
  4. TUG Timed Up and Go-Test.
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