Table 1 QCA performance: pre- vs. post-ACTH infusion.

From: Accuracy of semi-quantitative gold nanoparticle-based quick cortisol assay with and without adrenocorticotropic hormone infusion during adrenal vein sampling

 

Left Adrenal Vein

Right Adrenal Vein

Combined left and right adrenal veins

Pre-ACTH n = 48

Post-ACTH n = 34

Pre-ACTH n = 69

Post-ACTH n = 43

Pre-ACTH n = 117

Post-ACTH n = 77

True Positive (%)

21 (43.7)

32 (94.1)

29 (42.0)

33 (76.7)

50 (42.7)

65 (84.4)

True Negative (%)

6 (12.5)

2 (0.6)

27 (39.1)

10 (23.2)

33 (28.2)

12 (15.6)

False Positive (%)

14 (29.2)

0 (0)

9 (13)

0 (0)

23 (19.7)

0 (0)

False Negative (%)

7 (14.6)

0 (0)

4 (5.8)

0 (0)

11 (9.4)

0 (0)

Sensitivity % (95% CI)

75 (56.6–87.3)

100 (89.3–100)

87.9 (72.7–95.2)

100 (89.6–100)

82 (70.5–89.6)

100 (94.4–100)

Specificity % (95% CI)

30 (14.5–51.9)

100 (34.2–100)

75 (58.9–86.2)

100 (72.2–100)

58.9 (45.9–70.8)

100 (75.7–100)

Positive predictive value % (95% CI)

60 (43.6–74.4)

100 (89.3–100)

76.3 (60.8–87.0)

100 (89.6–100)

68.5 (57.1–77.9)

100 (94.4–100)

Negative predictive value % (95% CI)

46.2 (23.2–70.9)

100 (34.2–100)

87.1 (71.1–94.9)

100 (72.2–100)

75 (60.6–85.4)

100 (75.8–100)

  1. True positive, True negative, False positive and False negative data are expressed as number of QCA results and percentage in parentheses. QCA quick cortisol assay, CI confidence interval. For a description on the derivation of these statistical measures please refer to Supplementary Table 6.