Fig. 3
From: Diagnostic challenge of the newborn patients with heritable protein C deficiency
Predictive formulas for PROC mutation in infants with neonatal-onset PC deficiency. a The formula was drawn by the analysis on 24 infants having no defective variables (mutation: n = 15, nonmutation: n = 9) in the registry, consisting of 7 patients from publications and 17 patients analyzed in Kyushu University (panel a). The probability of mutation was calculated as follows; Logit(P) = 3.55-0.13 × PC activity-3.51 × PC/PS ratio. b The other formula was drawn by the analysis on 23 infants having no defective variables (mutation: n = 14, nonmutation: n = 9) in the registry, consisting of 7 patients from publications and 16 patients analyzed in Kyushu University (panel a). The probability of mutation was calculated as follows; Logit(P) = 3.26 − 0.12 × PC activity-3.24 × PC/PS + 0.04 × onset (day after birth). a, b The goodness of fit of the model was statistically significant assessed by the Hosmer–Lemeshow test (panel b)
