Table 2 Univariate analysis for variables associated with PROC mutation(s) in infants diagnosed with neonatal-onset PC deficiency
From: Diagnostic challenge of the newborn patients with heritable protein C deficiency
Cut-off | Sensitivity (%) | Specificity (%) | PPV (%) | NPV (%) | AUC (95% CI) | Odds ratio (95% CI) | p Value | |
|---|---|---|---|---|---|---|---|---|
PC activity | <10% | 71 | 92 | 95 | 60 | 0.82 (0.68–0.91) | 30.0 (3.33–270) | <0.01 |
Purpura fulminans | yes | 57 | 92 | 94 | 50 | 0.74 (0.61–0.85) | 16.0 (1.82–140) | 0.013 |
Manifestations | >1 | 54 | 92 | 94 | 48 | 0.73 (0.59–0.83) | 13.9 (1.58–121) | 0.017 |
Gestational age | >36 weeks | 93 | 31 | 76 | 67 | 0.67 (0.50–0.80) | 9.3 (1.47–58) | 0.018 |
Apgar score at 5 min | >7 | 93 | 36 | 82 | 75 | 0.72 (0.45–0.89) | 14.0 (1.06–185) | 0.045 |
PC activity/PS activity | <0.35 | 87 | 78 | 87 | 78 | 0.82 (0.59–0.93) | 22.7 (2.60–198) | <0.01 |
