Table 2 Behavioral, physiological, and biochemical signs of pain, ATP utilization, and oxidative stress.

From: Oral dextrose reduced procedural pain without altering cellular ATP metabolism in preterm neonates: a prospective randomized trial

Characteristics

30% dextrose

n = 47

Facilitated tucking

n = 53

30% dextrose and facilitated tucking

n = 52

P value*

PIPP-R: median (min, max)

  Baseline

5 (0, 17)

5 (0, 14)

6 (0, 13)

0.124

  Heel lance

7 (0, 15)

8 (0, 17)

8 (0, 16)

0.783

Heart rate, bpm

 Mean ± SD

   Baseline

162.78 ± 12.63

160.90 ± 19.10

167.02 ± 14.41

0.159

   Heel lance

165.02 ± 13.73

165.08 ± 13.34

162.70 ± 29.06

0.965

Minimum O2 sat during heel lance (%), mean ± SD

94.44 ± 4.69

91.33 ± 7.28

92.10 ± 5.77

0.052

Uric acid

  Baseline

145.82 (70.96)

119.84 (51.14)

136.57 (64.94)

0.08

  5 min

140.76 (73.11)

120.4 (49.48)

133.56 (65.72)

0.201

Hypoxanthine

  Baseline

1.35 (1.35)

1.35 (2.09)

1.37 (1.21)

0.739

  5 min

1.33 (1.29)

1.44 (2.17)

1.28 (1.13)

0.927

Allantoin

  Baseline

29.24 (18.29)

31.95 (24.17)

26.31 (13.83)

0.642

  5 min

27.83 (16.68)

30.72 (21.13)

26.78 (14.84)

0.75

  1. *Bivariate comparisons.