Table 3 Reasons for treatment failure and secondary outcomes.

From: A trial comparing continuous positive airway pressure (CPAP) devices in preterm infants

Outcome

Seattle-PAP (n = 112)

FP-CPAP (n = 120)

Risk Difference (95% CI)

P value

Reason for treatment failurea

Failure of successful transitionb

15 (13.4)

18 (15.0)

−1.6 (−10.6–7.4)

0.73

Increase in fraction of inspired oxygen

15 (13.4)

22 (18.3)

−4.9 (−14.3–4.4)

0.30

Escalation of respiratory care requiring intubationc

22 (19.6)

24 (20.0)

−0.4 (−10.6–9.9)

0.95

Escalation of respiratory care to SiPAP

3 (2.7)

0 (0)

2.7 (−0.3–5.7)

0.11

Number of days on mechanical ventilation after trial entry, median (IQR)d

0 (0–4)

0 (0–5)

NA

0.20

Number of days any positive pressure support after trial entry, median (IQR)e,f

47.5 (34.5–75.5)

51 (32–74)

NA

0.99

Number of days of oxygen therapy after trial entry, median (IQR)f

28.5 (5–91)

34 (5–84)

NA

0.63

Number of days on room air after trial entry, median (IQR)f

46 (19–57)

43 (20–60)

NA

0.93

Number of days to achieve full enteral feeding after trial entry, median (IQR)f,g

12.5 (10–14)

11 (10–14)

NA

0.73

Number of days to achieve full-suck feeding, median (IQR)f

73 (63–80)

78 (66–83)

NA

0.95

Weight at discharge (kg)f

3.1 (2.6–3.8)

3.0 (2.6–4.1)

NA

0.89

  1. Definition of room air includes infants who were on CPAP or nasal cannula with FiO2 of 0.21.
  2. SiPAP synchronized inspiratory positive airway pressure, IQR Interquartile range, NA Not applicable.
  3. aTreatment may have failed for more than one reason.
  4. bIntubation within 72 h for surfactant administration after initiation of bn-CPAP and then fails to meet extubation criteria by 72 h.
  5. cIntubation was recommended if more than two episodes of apnea requiring bag-mask ventilation were encountered or more than six episodes of apnea required stimulation in a 24 h period.
  6. dMechanical ventilation includes synchronized intermittent ventilation (SIMV) and high-frequency oscillatory ventilation (HFOV).
  7. eRespiratory support included the use of nasal continuous positive airway pressure, SIMV, and HFOV.
  8. fInfants who died before discharge were excluded (n = 8, Seattle PAP; n = 5, FP-CPAP).
  9. gFull enteral and full-suck feeding defined as feeds >130 mL/kg/day.
Back to article page