Table 1 Newborn demographic and health characteristics and hospital characteristics among birth hospitalizations with and without a documented COVID-19 diagnosis, PHDa, May 2020–February 2022b.

From: Critical care among newborns with and without a COVID-19 diagnosis, May 2020–February 2022

  

Overall

Period 1- Pre delta

Period 2 - Delta

Period 3 - Omicron

Characteristics

Total (n = 1,388,712)

COVID-19 (n = 876)

No COVID-19 (n = 1,387,836)

p-valuec

COVID-19 (n = 271)

No COVID-19 (n = 855,613)

p-valuec

COVID-19 (n = 226)

No COVID-19 (n = 336,394)

p-valuec

COVID-19 (n = 379)

No COVID-19 (n = 178,596)

p-valuec

Infant Characteristics

 Gender

   Female

678,788 (48.88)

423 (48.29)

678,365 (48.88)

0.7675

132 (48.71)

425,031 (48.86)

0.9338

106 (46.90)

164,863 (49.01)

0.7839

185 (48.81)

88,471(48.73)

0.9177

   Male

709,295 (51.08)

453 (51.71)

708,842 (51.08)

 

139 (51.29)

444,425 (51.09)

 

120 (53.10)

171,413 (50.96)

 

194 (51.19)

93,004 (51.23)

 

   Unknown

629 (0.05)

0 (0.00)

629 (0.05)

 

0 (0.00)

429 (0.05)

 

0 (0.00)

118 (0.04)

 

0 (0.00)

82 (0.05)

 

 Race and Ethnicityd

   Black, non- Hispanic

192,621 (13.87)

119 (13.58)

192,502 (13.87)

<0.0001

41 (15.13)

121,862 (14.01)

0.0010

31 (13.72)

45,763(13.60)

0.7086

47 (12.40)

24,877 (13.70)

0.0345

   Hispanic

234,302 (16.87)

202 (23.06)

234,100 (16.87)

 

65 (23.99)

137,271 (15.78)

 

45 (19.91)

62,424 (18.56)

 

92 (24.27)

34,405 (18.95)

 

   Other Unknown, non-Hispanic

289,478 (20.85)

148 (16.89)

289,330 (20.85)

 

42 (15.50)

18,0986 (20.81)

 

40 (17.70)

69,923 (20.79)

 

66 (17.41)

38,421(21.16)

 

   White, non-Hispanic

672,311 (48.41)

407 (46.46)

671,904 (48.41)

 

123 (45.39)

429,766 (49.40)

 

110 (48.67)

158,284 (47.05)

 

174 (45.91)

83,854(46.19)

 

 Insurance

   Medicaid

661,584 (47.64)

481 (54.91)

661,103 (47.64)

<0.0001

139 (51.29)

415,988 (47.82)

0.0784

117 (51.77)

157,890 (46.94)

0.0418

225 (59.37)

87,225 (48.04)

<0.0001

   Privatee

615,355 (44.31)

333 (38.01)

615,022 (44.32)

 

104 (38.38)

385,989 (44.37)

 

100 (44.25)

150,312 (44.68)

 

129 (34.04)

78,721 (43.36)

 

   Self-pay, Other

111,773(8.05)

62 (7.08)

111,711 (8.05)

 

28 (10.33)

67,908 (7.81)

 

9 (3.98)

28,192(8.38)

 

25 (6.60)

15,611 (8.60)

 

Infant Health Characteristics

 Gestational Age

   Full Term (37+ weeks)

1,251,732 (90.14)

698 (79.68)

1,251,034 (90.14)

<0.0001

195 (71.96)

784,176 (90.15)

<0.0001

168 (74.34)

302,937 (90.05)

<0.0001

335 (88.39)

163,921 (90.29)

0.2132

   Preterm (<37 weeks)

136,980 (9.86)

178 (20.32)

136,802(9.86)

 

76 (28.04)

85,709 (9.85)

 

58 (25.66)

33,457 (9.95)

 

44 (11.61)

17,636 (9.71)

 

    34-<37 weeks

110,503 (80.67)

108 (60.67)

110,395 (80.70)

<0.0001

42 (55.26)

68,582 (80.02)

<0.0001

32 (55.17)

26,977 (80.63)

<0.0001

34 (77.27)

14,836 (84.12)

0.2145

    <34 weeks

26,477 (19.33)

70 (39.33)

26,407 (19.30)

 

34 (44.74)

17,127 (19.98)

 

26 (44.83)

6480 (19.37)

 

10 (22.73)

2800(15.88)

 

 Small for Gestational Age

   Yes

64,593 (4.65)

37 (4.22)

64,556 (4.65)

0.5478

9 (3.32)

39,286 (4.52)

0.3434

14 (6.19)

16,163 (4.80)

0.3288

14 (3.69)

9107 (5.02)

0.2387

   No

1,324,119 (95.35)

839 (95.78)

1,323,280 (95.35)

 

262 (96.68)

830,599 (95.48)

 

212 (93.81)

320,231 (95.20)

 

365 (96.31)

172,450 (94.98)

 

 Status at Discharge

   Deceased/ hospice

3800 (0.27)

3 (0.34)

3797(0.27)

<0.0001

1 (0.37)

2502 (0.29)

0.0002

1 (0.44)

847(0.25)

<0.0001

1(0.26)

448 (0.25)

0.9574

   Home

1,347,745 (97.05)

825 (94.18)

1,346,920 (97.05)

 

251 (92.62)

843,485 (96.97)

 

205 (90.71)

326,812 (97.15)

 

369 (97.36)

176,623 (97.28)

 

   Other facility

36,068 (2.60)

47 (5.37)

36,021 (2.60)

 

19(7.01)

23,218 (2.67)

 

19 (8.41)

8465 (2.52)

 

9 (2.37)

4338(2.39)

 

   Other/Unknown

1099 (0.08)

1(0.11)

1098 (0.08)

 

0 (0.00)

680(0.08)

 

1 (0.44)

270 (0.08)

 

0 (0.00)

148 (0.08)

 

 Urbanicity

   Rural

182,010(13.11)

102 (11.64)

181,908 (13.11)

0.1995

29 (10.70)

114,217 (13.13)

0.2365

33 (14.60)

43,678(12.98)

0.4696

40 (10.55)

24,013(13.23)

0.1250

   Urban

1,206,702 (86.89)

774 (88.36)

1,205,928 (86.89)

 

242(89.30)

755,668 (86.87)

 

193 (85.40)

292,716 (87.02)

 

339 (89.45)

157544 (86.77)

 

 US Census Regionf

   Midwest

331,399 (23.86)

223 (25.46)

331,176 (23.86)

<0.0001

75 (27.68)

208,348 (23.95)

0.1612

47 (20.80)

79,777 (23.72)

<0.0001

101 (26.65)

43,051 (23.71)

0.1419

   Northeast

179,650 (12.94)

90 (10.27)

179,560 (12.94)

 

27 (9.96)

112,974 (12.99)

 

13 (5.75)

43,513 (12.94)

 

50 (13.19)

23,073 (12.71)

 

   South

631,142 (45.45)

447 (51.03)

630,695 (45.44)

 

129 (47.60)

394,201 (45.32)

 

141 (62.39)

153,295 (45.57)

 

177 (46.70)

83,199 (45.83)

 

   West

246,521 (17.75)

116 (13.24)

246,405 (17.75)

 

40 (14.76)

154,362 (17.75)

 

25 (11.06)

59,809 (17.78)

 

51 (13.46)

32,234 (17.75)

 
  1. COVID-19 coronavirus disease 2019, PHD Premier Healthcare Database Special COVID-19 release.
  2. aPremier Healthcare Database, 523 U.S. hospitals with birth hospitalizations.
  3. bPre-delta: May 2020–May 2021; Delta: June–November 2021; Omicron: December 2021–February 2022.
  4. cP value associated with Pearson chi-square tests unless otherwise noted; significant results are bolded.
  5. dRace and Hispanic origin were collected separately but combined for this analysis. Newborns who had unknown Hispanic origin were assumed to be non-Hispanic if race was available.
  6. eIncludes managed care and commercial indemnity.
  7. fThe U.S. Census defines an urban area as a territory whose core census block groups or blocks have a population density of at least 1000 people per square mile, and surrounding census blocks have an overall density of at least 500 people per square mile. Rural areas are considered territories outside the definition of urban.