Fig. 2: Change in serum electrolyte after novel diuretic exposure.

Figure depicts the unadjusted change in serum sodium, potassium, and chloride after novel chlorothiazide and furosemide exposure. No significant difference was noted between furosemide and chlorothiazide with regard to change in serum sodium (−0.9 vs −1.9 mmol/L, p = 0.25) or chloride (−3.1 vs −4.5 mmol/L, p = 0.19). Compared to novel furosemide, novel chlorothiazide was associated with greater change in serum potassium (−0.0 vs −0.6, p = 0.008).