Fig. 2: Metabolic effects or rapid administration of intravenous sodium bicarbonate.
From: ABCs of base therapy in neonatology: role of acetate, bicarbonate, citrate and lactate
Although intravascular correction of pH and alkalosis occurs, due to better diffusion of carbon dioxide into the cells (compared to bicarbonate ion), intracellular acidosis can occur, especially in cardiomyocytes. High osmolar load and fluctuations in cerebral blood flow can contribute to intraventricular hemorrhage. Copyright Satyan Lakshminrusimha.
