Table 4 Summary of effects of treatment methods on lipids, lactose and protein in breastmilk.

From: Strategies to reduce CMV infectivity in breastmilk to preterm babies – impact on transmission, nutrients, and bioactivity: a systematic review and meta-analysis

Treatment methods

Author

Effect of treatment on (% reduction)

Lactose

Lipids

Protein

Freeze-thawing

Friend et al. [43]

x

NS

x

(−20C for variable durations)

Yuen et al. [13]

NS

NS

NS

 

Garcia-lara et al. [44]

NS

NS

NS

 

Paduraru et al. [45]

NS

x

x

 

Tanriverdi et al. [46]

NS

Significant decrease

NS

Freeze-Thawing (4C for variable durations)

Ezz El Dinn et al. [47]

NS

NS

NS

 

Yuen et al. [13]

59% increase

Slight decrease

Slight decrease

 

Paduraru et al. [45]

NS

NS

NS

Holder pasteurization

Garcia-lara et al. [44]

NS

0.062

x

Meredith-Dennis et al. [48]

x

0.209

Significant decrease

Lima et al. [49]

NS

NS

~2%

Adhisivam et al. [51]

0.16

0.25

0.125

Piemontese et al. [52]

0.0111

0.0549

0.0227

Pitino et al. [53]

NS

NS

NS

Lima et al. [50]

NS

NS

0.0126

Chang et al. [11]

x

0.2045

NS

Caballero Martin et al. [54]

NS

0.062

NS

Lamb et al. [55]

NS

NS

NS

Martysiak Zurowska et al. [56]

NS

NS

NS

High Temperature short time

Pitino et al. [53]

NS

NS

NS

Microwave irradiation

Martysiak Zurowska et al. [56]

NS

NS

NS

UV-C irradiation

Pitino et al. [53]

NS

NS

NS

High pressure processing

Pitino et al. [53]

Slight decrease

NS

NS

  1. NS Not Statistically Significant, x Data not reported/available in article.