Table 1 Patient demographics.

From: Management of the patent ductus arteriosus among infants born at 23 to 32 weeks’ gestation between 2011 to 2022: a report from in the Children’s Hospitals Neonatal Consortium

 

Total cohort

(1) 2011–2013

(2) 2014–2016

(3) 2017–2019

(4) 2020–2022

p

Total patients, n

54,813

10,681

12,894

14,726

16,512

 

Patients with PDA diagnosis, n (%)

19,843 (36.2)

4051 (37.9)

4732 (36.7)

5257 (35.7)

5803 (35.1)

CHNC centers, n

45

27

32

34

45

Gestational age, weeks, median (IQR)

26 [24,28]

26 [24,28]

26 [24,28]

26 [24,28]

26 [24,28]

0.397

GA 23–24 weeks, n (%)

5911 (29.8)

1126 (27.8)

1425 (30.1)

1588 (30.2)

1772 (30.5)

0.035

GA 25–26 weeks, n (%)

6426 (32.4)

1404 (34.7)

1533 (32.4)

1683 (32)

1806 (31.1)

GA 27–28 weeks, n (%)

4000 (20.2)

810 (20)

956 (20.2)

1061 (20.2)

1173 (20.2)

GA 29–30 weeks, n (%)

2032 (10.2)

426 (10.5)

453 (9.6)

528 (10)

625 (10.8)

GA 31–32 weeks, n (%)

1474 (7.4)

285 (7)

365 (7.7)

397 (7.6)

427 (7.4)

Female, n (%)

8931 (45)

1785 (44.1)

2124 (44.9)

2368 (45)

2654 (45.7)

0.430

Male, n (%)

10,901 (54.9)

2264 (55.9)

2605 (55.1)

2887 (54.9)

3145 (54.2)

Birthweight, g, median (IQR)

810 [650,1052]

813 [660,1060]

810 [650,1050]

809 [650,1060]

803 [640,1050]

0.067

 <750

8041 (40.5)

1576 (38.9)

1905 (40.3)

2138 (40.7)

2422 (41.7)

0.246

 750–999

5909 (29.8)

1264 (31.2)

1423 (30.1)

1538 (29.3)

1684 (29)

 1000–1499

4215 (21.2)

865 (21.4)

1001 (21.2)

1144 (21.8)

1205 (20.8)

 ≥1500

1592 (8)

330 (8.1)

377 (8)

408 (7.8)

477 (8.2)

Birthweight <10th percentile, n (%)

3189 (16.1)

597 (14.7)

693 (14.6)

875 (16.6)

1024 (17.6)

<0.001

Cesarean delivery, n (%)

13,827 (69.7)

2757 (68.1)

3236 (68.4)

3654 (69.5)

4180 (72)

<0.001

Antenatal steroids, n (%)

12,187 (61.4)

2259 (55.8)

2867 (60.6)

3277 (62.3)

3784 (65.2)

<0.001

Multiple gestation, n (%)

4875 (24.6)

1084 (26.8)

1182 (25)

1237 (23.5)

1372 (23.6)

0.001

Age at NICU admission, days, median (IQR)

19 [2,56]

18 [2,50]

18 [2,54]

21 [2,67]

19 [1,53]

<0.001

Inborn, n (%)

909 (4.6)

20 (0.5)

57 (1.2)

139 (2.6)

693 (11.9)

.

Born at co-located hospital, n (%)

1496 (7.5)

232 (5.7)

446 (9.4)

483 (9.2)

335 (5.8)

.

Outborn, n (%)

17,438 (87.9)

3799 (93.8)

4229 (89.4)

4635 (88.2)

4775 (82.3)

<0.001

  1. Data presented as median (interquartile range, IQR) or number (percentage).
  2. CHNC Children’s Hospitals Neonatal Consortium, GA Gestational age.
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