Table 1 Demographic and clinical characteristics.

From: Associations between antibiotic exposure intensity, intestinal microbiome perturbations, and outcomes in premature neonates with bacteremia

 

Case (n = 40)

Control (n = 39)

p-value

Male sex, n (%)

22 (55)

25 (64)

0.68

Gestational age (weeks), mean (SD)

27.1 (22.1)

27.5 (15)

0.29

Birth weight (kg), mean (SD)

0.93 (0.34)

0.96 (0.2)

0.61

Multiple gestation, n (%)

9 (23)

4 (10)

0.22

Vaginal birth, n (%)

10 (25)

5 (12)

0.35

Hispanic ethnicity, n (%)

7 (18)

3 (8)

0.31

Race, n (%)

 White

20 (50)

20 (51)

0.9

 Black

14 (35)

12 (31)

 

 Other or unknown

6 (15)

7 (18)

 

 Mortality, n (%)

4 (10)

0 (0)

 Length of admission in days, mean (SD)

141 (94.5)

77 (26.5)

<0.001

 Nutrition/diet by stool sample

(n = 383 samples)

(n = 249 samples)

 

Enteral feedinga, n stools (% stools)

 Maternal breast milk (MBM)

157 (41)

141 (57)

<0.001

 Donor breast milk (DBM)

81 (21)

90 (36)

 

 Formula

190 (50)

78 (31)

 

 None/NPO

62 (16)

5 (2)

 

Maternal chorioamnionitisb, n (%)

 Yes

9 (23)

8 (21)

0.98

 No

20 (50)

20 (51)

 

 Unknown

11 (28)

11 (28)

 

Maternal antibiotics, n (%)

 Any perinatal antibiotics

32 (80)

30 (77)

0.74

 None

5 (13)

0 (0)

 Unknown

3 (8)

9 (23)

  1. P-values computed using independent t-test for continuous variables, chi-square or Fisher Exact Test for categorical variables with statistical significance defined as p <0.05.
  2. aEnteral feeding describes all diets received by the subject in the 7 days prior to a collected stool sample. In a given week a subject could have multiple feeding regimens; hence percentages add to >100%; NPO, nothing by mouth.
  3. bChorioamnionitis was based on histologic evaluation of placenta.