Table 5 Neurodevelopment at 12 to 18 months’ corrected age.

From: Gestational diabetes detection thresholds and infant growth, nutrition, and neurodevelopment at 12-18 months: a prospective cohort study within a randomized trial

 

Control

N

Group A

GDM by lower but not higher criteria: treated

N

Adjusted RD or MD (95% CI)

OR [95% CI]

Group B

GDM by lower but not higher criteria: untreated

N

Adjusted RD or MD (95% CI)

OR [95% CI]

Group C

GDM by higher criteria treated

N

Adjusted RD or MD (95% CI)

OR [95% CI]

(CAT)

Low cognitive score

10 (8%)

121

19 (13%)

143

4 (−8, 15)

1.5 [0.5, 4.0]

14 (11%)

131

2 (−10, 12)

1.1 [0.4, 3.2]

12 (7%)

171

−2 (−15, 9)

0.7 [0.2, 1.9]

(ASQ-3)

Communication score

46 (13)

122

49 (11)

147

2.3 (−1.0, 5.5)

49 (11)

138

2.7 (−0.6, 6.0)

50 (11)

175

2.5 (−0.7, 5.8)

Low communication score

24 (20%)

122

16 (11%)

147

−6 (−20, 7)

1.7 [0.7, 4.1]

14 (10%)

138

−9 (−20, 7)

1.9 [0.8, 4.5]

13 (7%)

175

−11 (−22, 5)

2.4 [1.0, 6.1]

Gross motor score

45 (18)

122

44 (18)

147

−2.3 (−6.9, 2.2)

48 (15)

138

1.6 (−2.9, 6.2)

48 (14)

175

0.6 (−3.9, 5.1)

Low gross motor score

27 (22%)

122

39 (27%)

147

7 (−5, 20)

0.7 [0.3, 1.3]

31 (22%)

138

3 (−6, 18)

0.8 [0.4, 1.7]

36 (21%)

175

−2 (−16, 8)

0.8 [0.4, 1.7]

Personal-social score

42 (14)

122

41 (15)

147

−1.1 (−5.2, 3.0)

45 (14)

139

2.7 (−1.3, 6.8)

43 (15)

175

0.4 (−3.6, 4.5)

Low personal-social score

31 (25%)

122

40 (27%)

147

2 (−13, 12)

0.9 [0.5, 1.8]

24 (17%)

139

−10 (−22, 3)

1.6 [0.8, 3.4]

45 (26%)

175

1 (−12, 13)

1.0 [0.5, 1.9]

  1. Data are mean (standard deviation) or number (percent). ASQ low scores defined as 1 or 2 standard deviations below the test mean. Low cognitive scores defined as 1 standard deviation below the test mean. Analyses adjusted for potential confounding by maternal body size (body mass index), socioeconomic status (New Zealand Deprivation Index), ethnicity and infant sex, with Dunnett correction of family-wise error rate.
  2. ASQ-3 Ages and Stages Questionnaire, version 3, MD mean difference, OR odds ratio, RD risk difference, CAT Cognitive Adaptive Test.