Table 3 Trends of key outcomes by unadjusted and adjusted logistic regression models.

From: Trends of care patterns and outcomes of very low birth weight infants (≤1500 g) born after 27 weeks of gestation in South Wales, UK

Outcomes

Unadjusted odds ratio (confidence intervals)

Adjusted odds ratio (confidence intervals)

Other Independent Variables, odds ratio (confidence intervals)

All infants (n = 2321)

 Mortality

0.932 (0.889, 0.977)

0.941 (0.895, 0.988)

SGA: 2.784 (1.775, 4.366)

Gestation: 0.726 (0.638, 0.827)

Admission temperature: 0.727 (0.549, 0.962)

 Severe brain injury (IVH grade III-IV

OR PVL by CUSS)

0.933 (0.891, 0.977)

0.937 (0.893, 0.982)

No antenatal steroids: 3.210 (1.941, 5.309)

Gestation: 0.661 (0.559, 0.781)

 ROP intervention

0.897 (0.805, 1)

0.901 (0.808, 1.004)

C Section: 4.522 (1.041, 19.647)

Gestation: 0.69 (0.506, 0.939)

 BPD

(from 2011)

1.03 (0.983, 1.08)

1.036 (0.985, 1.089)

Gestation: 0.681 (0.613, 0.757) SGA: 2.349 (1.597, 3.456)

Out-born: 1.619 (1.032, 2.541)

Male: 1.789 (1.279, 2.503)

Vaginal delivery: 0.562 (0.368, 0.859)

 NEC

0.912 (0.863, 0.964)

0.911 (0.862, 0.964)

Gestation: 0.761(0.653, 0.887)

 Any sepsis during stay

0.952 (0.924, 0.981)

0.949 (0.920, 0.978)

C Section: 1.594 (1.179, 2.156)

Gestation: 0.749 (0.689, 0.815)

 Delivery room ventilation

0.926 (0.908, 0.945)

0.909 (0.888, 0.930)

SGA: 1.651 (1.300, 2.096)

Multiple births: 0.788 (0.631, 0.984)

No Antenatal steroids: 1.754 (1.231, 2.500)

Gestation: 0.468 (0.432, 0.507)

 Delivery room surfactant

0.936 (0.917, 0.955)

0.920 (0.899, 0.942)

SGA: 1.724 (1.353, 2.198)

No Antenatal steroids: 1.635 (1.148, 2.329)

Gestation: 0.443 (0.407, 0.482)

 Ventilation after admission

0.955 (0.937, 0.974)

0.940 (0.919, 0.961)

SGA: 1.598 (1.260, 2.028)

Males: 1.344 (1.109, 1.630)

Outborn: 1.703 (1.346, 2.155)

No Antenatal steroids: 1.764 (1.217, 2.558)

Gestation: 0.501 (0.466, 0.540)

Very preterm infants (n = 1797)

 Mortality

0.924 (0.878, 0.974)

0.935 (0.886, 0.987)

SGA: 2.693 (1.613, 4.497)

Gestation: 0.655 (0.528, 0.813)

Admission temperature: 0.682 (0.505, 0.922)

 Severe brain injury (IVH grade III-IV

OR PVL by CUSS)

0.923 (0.879, 0.969)

0.926 (0.880, 0.974)

SGA: 0.435 (0.226, 0.839)

No antenatal steroids: 3.735 (2.186, 6.382)

Gestation: 0.541 (0.432, 0.679)

 ROP intervention

0.854 (0.753, 0.970)

0.865 (0.760, 0.985)

Gestation: 0.459 (0.271, 0.776)

 BPD

(from 2011)

0.883 (0.846, 0.921)

0.891 (0.851, 0.934)

SGA: 2.584 (1.706, 3.914)

Male: 2.021 (1.406, 2.906)

C Section: 1.841 (1.192, 2.842)

Gestation: 0.547 (0.461, 0.649)

 NEC

0.908 (0.856, 0.962)

0.911 (0.858, 0.967)

Gestation: 0.679 (0.534, 0.864)

Non-white ethnicity: 2.490 (1.254, 4.945)

 Any sepsis during stay

0.952 (0.922, 0.983)

0.956 (0.924, 0.988)

Gestation: 0.679 (0.592, 0.780)

C Section: 1.601 (1.138, 2.251)

 Delivery room ventilation

0.912 (0.891, 0.933)

0.900 (0.878, 0.923)

SGA: 1.383 (1.053, 1.816)

Male: 1.296 (1.048, 1.603)

No antenatal steroids: 1.730 (1.171, 2.556)

C Section: 1.395 (1.098, 1.771)

Gestation: 0.404, (0.360, 0.452)

 Delivery room surfactant

0.918 (0.898, 0.939)

0.907 (0.884, 0.930)

SGA: 1.426 (1.081, 1.881)

Male: 1.347 (1.086, 1.670)

No antenatal steroids: 1.689 (1.143, 2.495)

C Section: 1.478 (1.161, 1.882)

Gestation: 0.378 (0.336, 0.424)

 Ventilation after admission

0.937 (0.916, 0.959)

0.928 (0.905, 0.953)

SGA: 1.397 (1.055, 1.850)

Outborn: 1.641 (1.257, 2.142)

Male: 1.502 (1.207, 1.870)

No antenatal steroids: 1.830 (1.187, 2.820)

C Section: 1.817 (1.422, 2.321)

Gestation: 0.423, (0.377, 0.475)

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