Fig. 1 | Laboratory Investigation

Fig. 1

From: Maresin 1 attenuates mitochondrial dysfunction through the ALX/cAMP/ROS pathway in the cecal ligation and puncture mouse model and sepsis patients

Fig. 1

MaR1 protected lung tissues and increased the survival rate in cecal ligation and puncture (CLP)-induced Sepsis. MaR1 (100ng/mice, i.p.) was administered to C57BL/6 mice after surgery or 6 h after CLP, survival rate was observed for 8 days (a). Slight CLP model was also used to observe the effect of MaR1 (b). The lung tissues were collected 24 h after CLP and the effect of MaR1 was assessed by histology in H&E-stained sections(original magnification × 100) (c). Lung injury scores (d) were recorded from 0 (no damage) to 16 (maximum damage) according to the criteria described in Materials and Methods. Data are presented as mean ± SEM. n = 6–12. *p < 0.05, **p < 0.01 vs. SHAM group. #p < 0.05, ##p < 0.01 vs. CLP group

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