Fig. 10 | Laboratory Investigation

Fig. 10

From: Maresin 1 attenuates mitochondrial dysfunction through the ALX/cAMP/ROS pathway in the cecal ligation and puncture mouse model and sepsis patients

Fig. 10

MaR1 decreased mitochondrial membrane potential in BMDM stimulated with LPS. BMDM were treated with MaR1 (10 nM) in the presence or absence of LPS (100 ng/ml) for 6 h, then stained with 2.5 mmol/l of JC-1, a membrane potential-sensitive fluorescent dye. The dye was loaded, and after 30 min incubation fluorescent microscopic images were taken using both the red and green channels (a). Flow cytometry (b) was also used to measure the mitochondrial membrane potential in BMDM stimulated with LPS using JC-1 dye

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