Fig. 11 | Laboratory Investigation

Fig. 11

From: Maresin 1 attenuates mitochondrial dysfunction through the ALX/cAMP/ROS pathway in the cecal ligation and puncture mouse model and sepsis patients

Fig. 11

MaR1 improved mitochondrial DNA (mtDNA) copy number and ATP content in BMDM stimulated with LPS. BMDM were treated with MaR1 (10 nM) with or without of LPS (100 ng/ml) for 6 h. After incubation, the cells were collected and sonicated. RT-PCR was used to detect mtDNA copy number (a). Firefly luciferase ATP assay kit was used to measure ATP content (b). Data are presented as mean ± SEM. n = 6. *p < 0.05, **p < 0.01 vs. CLP group. #p < 0.05 vs. LPS group. &p < 0.05 vs. LPS+MaR1 group

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