Fig. 4 | Laboratory Investigation

Fig. 4

From: SOCS1-targeted therapy ameliorates renal and vascular oxidative stress in diabetes via STAT1 and PI3K inhibition

Fig. 4

Antioxidant status of SOCS1-treated mice. a, b Real-time PCR analysis of antioxidant genes in tissue samples and peritoneal macrophages (MΦ) from diabetic mice treated with SOCS1-recombinant adenovirus (a) and SOCS1 peptidomimetic (b). Real-time PCR values were calculated after normalization to 18S rRNA and expressed as relative mRNA level compared with non-diabetic mice. c Measurement of total antioxidant capacity (TAC) in serum and urine samples. Bars are the mean ± SEM of 6–10 mice per group. Horizontal dotted lines represent the mean values for non-diabetic mice. *P < 0.05 vs Control, #P < 0.05 vs Ad-null, $P < 0.05 vs respective Veh (early or late model), and &P < 0.05 vs Mut

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