Table 2 Correlation of oxidative stress markers with parameters of renal injury in diabetic mice
ROS PRODUCTION DHE fluorescence (%) | DNA OXIDATION 8-OHdG staining (%) | |||
|---|---|---|---|---|
GLOM Pearson’s r (P value) | TUB-INT Pearson’s r (P value) | GLOM Pearson’s r (P value) | TUB-INT Pearson’s r (P value) | |
UACR (μg/μmol) | 0.7293 (<0.0001) | 0.8162 (<0.0001) | 0.3498 (0.0290) | 0.5745 (0.0002) |
srCre (mmol/L) | 0.7753 (<0.0001) | 0.7716 (<0.0001) | 0.7759 (<0.0001) | 0.7521 (<0.0001) |
Fibrosis (%) | 0.7823 (<0.0001) | 0.7145 (<0.0001) | 0.8085 (<0.0001) | 0.6824 (<0.0001) |
Kim1 mRNA (a.u.) | 0.8177 (<0.0001) | 0.8235 (<0.0001) | 0.7830 (<0.0001) | 0.8003 (<0.0001) |
Ccl2 mRNA(a.u.) | 0.743 (<0.0001) | 0.7826 (<0.0001) | 0.7675 (0.0003) | 0.7769 (0.0002) |
8-OHdG (%) | 0.8743 (<0.0001) | 0.8314 (<0.0001) | – | – |
Nox1 (%) | 0.6680 (<0.0001) | 0.8125 (<0.0001) | 0.6052 (<0.0001) | 0.7897 (<0.0001) |
Nox4 (%) | 0.8115 (<0.0001) | 0.8064 (<0.0001) | 0.8135 (<0.0001) | 0.7787 (<0.0001) |
Sod1 mRNA(a.u.) | –0.6436 (0.0053) | −0.6436 (0.0053) | −0.4463 (n.s.) | −0.4392 (n.s.) |
Hmox1 mRNA (a.u.) | −0.6491 (0.0048) | −0.6491 (0.0048) | −0.0221 (0.0221) | –0.3956 (n.s.) |
urTAC (mmol/L) | −0.7037 (<0.0001) | −0.5677 (0.0001) | −0.5883 (0.0003) | −0.6360 (<0.0001) |
