Fig. 5
From: BMP-2 restoration aids in recovery from liver fibrosis by attenuating TGF-β1 signaling
Effects of adenovirus-mediated BMP-2 gene delivery on BDL- and CCl4-induced liver fibrosis of mice. Mice received prophylactic treatment with adenovirus carrying BMP-2 (Ad-BMP-2) or GFP (Ad-GFP) as vehicle control at 1 day before undergoing BDL surgery or consecutive CCl4 administration. Liver tissues were collected after 2 and 4 weeks, respectively. a H&E staining of mouse fibrotic livers with Ad-GFP or Ad-BMP-2 treatment. Arrows indicate hepatic infarct areas. b Metavir fibrosis in both models. c Sirius red (SR) staining of mouse fibrotic livers with Ad-GFP or Ad-BMP-2 treatment. Arrows indicate collagen fibril bundles. d Quantification of SR-positive area. Data represent the mean ± SEM of six samples per group. *P < 0.05 compared between the indicated groups
