Fig. 2 | Laboratory Investigation

Fig. 2

From: Attenuation of ventilation-induced diaphragm dysfunction through toll-like receptor 4 and nuclear factor-κB in a murine endotoxemia model

Fig. 2

SN50 suppressed endotoxin-augmented mechanical ventilation-mediated oxidative stress and inflammatory cytokines production. (a) MDA (diaphragm), (b) protein carbonyl groups (diaphragm), (c) total antioxidant capacity (diaphragm), (d) SOD (diaphragm), (e) BAL fluid MIP-2, and f BAL fluid IL-6 were from the nonventilated control mice and mice ventilated at a tidal volume of 6 mL/kg or 10 mL/kg for 8 h with or without LPS administration (n = 5 per group). SN-50 2 mg/kg was given intraperitoneally 30 min before ventilation. *P < 0.05 versus the nonventilated control mice with LPS treatment; †P < 0.05 versus all other groups. BAL bronchoalveolar lavage, IL interleukin, MIP-2 macrophage inflammatory protein-2, MDA malondialdehyde, SOD sodium dismutase

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