Fig. 2 | Laboratory Investigation

Fig. 2

From: Interferon-γ mediates the protective effects of soluble receptor for advanced glycation end-product in myocardial ischemia/reperfusion

Fig. 2

Neutralization of IFN-γ reversed the inhibiting effects of sRAGE on MI/R-induced injuries. a Representative images of Evans blue and TTC staining in hearts. The blue area indicates viable tissue. The white area indicates infarct tissue. The area of red plus white indicates AAR. b Quantification of AAR/total area ratio in each group. c Quantification of infarct area/AAR ratio in each group. d Representative image of TUNEL and α-actinin staining in mouse hearts with or without sRAGE and anti-IFN-γ antibody treatment. Magnification: × 20. Scale bar: 50 μm. e Quantification of TUNEL-positive cells in fold-change over sham mice in each group. f Representative image of western blot for caspase-3 in mouse hearts with or without sRAGE and anti-IFN-antibody treatment. g Quantification of the relative expression of caspase-3 in mouse hearts. Values are expressed as the mean ± SEM (n = 7 mice per group). *p < 0.05; ***p < 0.001

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