Fig. 4 | Laboratory Investigation

Fig. 4

From: Interferon-γ mediates the protective effects of soluble receptor for advanced glycation end-product in myocardial ischemia/reperfusion

Fig. 4

Neutralization of IFN-γ reversed the inhibiting effects of sRAGE on signaling molecules in MI/R-treated hearts. a Representative image of western blot for phosphorylated p38, p38, phosphorylated JNK1/2, JNK1/2 and p53 in mouse hearts with or without sRAGE and anti-IFN-antibody treatment. b Quantification of the relative expression of phosphorylated p38/p38 in mice hearts. c Quantification of the relative expression of phosphorylated JNK1/JNK1 in mouse hearts. d Quantification of the relative expression of phosphorylated JNK2/JNK2 in mouse hearts. e Quantification of the relative expression of p53 in mouse hearts. Values are expressed as the mean ± SEM (n = 6 mice per group). *p < 0.05; **p < 0.01; ***p < 0.001

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