Fig. 6

Knockdown of β5i abolished the inhibiting effects of sRAGE on signaling molecules in H/R-treated cardiomyocytes. a Representative image of western blot for the β5i subunit, phosphorylated p38, p38, phosphorylated JNK1/2, JNK1/2 and p53 in cardiomyocytes. b Quantification of the relative expression of β5i in cardiomyocytes. c Quantification of the relative expression of p53 in cardiomyocytes. d Quantification of the relative expression of phosphorylated p38/p38 in cardiomyocytes. e Quantification of the relative expression of phosphorylated JNK1/JNK1 in cardiomyocytes. f Quantification of the relative expression of phosphorylated JNK2/JNK2 in cardiomyocytes. g Representative images of ubiquitinated p53 in each group. Values are expressed as the mean ± SEM from three independent experiments. *p < 0.05