Table 3 Association between human GEO deposits’ geographic origin (North America vs. other regions) and their corresponding disease area (related to a major disease area or unclassified) from 2001 to 2017

	North America		Other regions
Year	Related to major disease area	Unclassified	Related to major disease area	Unclassified	OR	95% CI	P value
2001	0	0	0	0	-	-	-
2002	19	16	2	1	0.59	0.05–7.17	>0.99
2003	44	109	13	20	0.62	0.28–1.36	0.297
2004	87	105	29	47	1.34	0.78–2.31	0.339
2005	168	157	86	57	0.71	0.48–1.06	0.107
2006	203	173	144	92	0.75	0.54–1.04	0.094
2007	312	210	199	139	1.04	0.79–1.37	0.831
2008	414	227	321	207	1.18	0.93–1.49	0.201
2009	522	338	447	292	1.01	0.83–1.23	0.959
2010	601	425	599	401	0.95	0.79–1.13	0.557
2011	814	552	768	514	0.99	0.84–1.15	0.874
2012	844	588	1026	630	0.88	0.76–1.02	0.09
2013	954	716	1103	741	0.90	0.78–1.02	0.107
2014	1001	757	1303	941	0.95	0.84–1.08	0.479
2015	1206	839	1419	1087	1.10	0.98–1.24	0.117
2016	1394	2192	1481	1080	0.46	0.42–0.51	6.84E−49
2017	1248	3709	1586	1353	0.29	0.26–0.32	3.46E−145
Total	9831 (25.2%)	11,113 (28.4%)	10,526 (26.9%)	7602 (19.5%)	0.64	0.61–0.67	5.02E−107

Note: Odds ratio (OR) represents the odds that a disease-specific GEO deposit originated from North America. The 6 major disease areas were cancer, cardiovascular diseases, diabetes, immunologic diseases, infectious diseases, and neurologic diseases, while all deposits not fitting in any of the six disease areas were categorized as unclassified. CI confidence intervals

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