Fig. 4 | Laboratory Investigation

Fig. 4

From: Mitochondrial pyruvate carrier 1 functions as a tumor suppressor and predicts the prognosis of human renal cell carcinoma

Fig. 4

Involvement of MPC1 in the migration and invasion of RCC cells through MMPs pathway. a The mRNA levels of MPC1, MMP7, and MMP9 in 786-O cells transfected with siCtrl and siMPC1 detected by qPCR. b MPC1, MMP7, and MMP9 proteins in 786-O cells transfected with siCtrl and siMPC1 detected by Western blotting. GAPDH serves as a loading control. c qPCR analysis of mRNA levels of MMP7 and MMP9 in 786-O cells treated with UK5099, *P < 0.05. d The expression of MMP7 and MMP9 in 786-O cells treated with UK5099 was analyzed by Western blotting. GAPDH serves as a loading control. e The mRNA levels of MPC1, MMP7, and MMP9 in 786-O cells transfected with Mock or MPC1 (OE-MPC1), *P < 0.05. f The expression of MPC1, MMP7, and MMP9 in 786-O cells transfected with Mock or MPC1 (OE-MPC1) detected by Western blotting. GAPDH serves as a loading control

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