Fig. 3
Approaches based on Lateral flow assay. a Generalized strategies to detect miRNAs using the lateral flow assay (LFA). b Schematic description of miRNA detection using lateral flow nucleic acid strips with gold nanoparticles (adapted from ref. [72]). c Schematic diagram of the hybridization reaction between the miRNA-capture probe-detector followed by enzyme-mediated signal enhancement of the lateral flow strip (adapted from ref. [73]). d The principle of the pH-responsive NRCA-based colorimetric assay for detection of miRNA followed by the equation of the reaction catalyzed by Bst DNA polymerase. The color changes of the pH-responsive indicators under different pH (figure adapted with permission from ref. [74])
