Fig. 5 | Laboratory Investigation

Fig. 5

From: MEF2B is a member of the BCL6 gene transcriptional complex and induces its expression in diffuse large B-cell lymphoma of the germinal center B-cell-like type

Fig. 5

a Pattern of expression of BCL6, CD10, and MEF2B by IHC in a normal germinal center control (left-side pictures) and in a core of DLBCL expressing the three proteins (right-side pictures). MEF2B shows nuclear expression similar to BCL6. b Receiver operating characteristic (ROC) curve for determining the cutoff value of MEF2B for diagnosing GC-DLBCL. In the plot, the highest specificity is reached at a cutoff for MEF2B positivity at an H-score of 105. The area under the ROC value is 0.76, indicating a high predictive power

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