Table 1 Cardiac morphometry, hemodynamics, and echocardiographic findings at the end of the study

From: Preconditioned adipose-derived stem cells ameliorate cardiac fibrosis by regulating macrophage polarization in infarcted rat hearts through the PI3K/STAT3 pathway

Parameters

Infarction treated with

Sham

Vehicle

ADSC

ADSC/BP

ADSC/BP/Li

ADSC/BP/LY

ADSC/BP/S3I

No. of rats

10

10

10

11

10

9

8

Mortality, n (%)

0 (0)

5 (33%)

4 (29%)

3 (21%)

3 (23%)

4 (31%)

4 (33%)

Body weight, g

305 ± 12

298 ± 10

312 ± 15

308 ± 14

272 ± 12#

307 ± 13

315 ± 13

HR, bpm

398 ± 11

415 ± 14

409 ± 12

410 ± 15

412 ± 14

405 ± 12

415 ± 17

LVESP, mmHg

97 ± 4

93 ± 5

95 ± 5

96 ± 6

93 ± 7

94 ± 5

97 ± 6

LVEDP, mmHg

6 ± 2

18 ± 4*

15 ± 3*

15 ± 3*

14 ± 5*

16 ± 4*

17 ± 5*

LVW/BW, mg/g

1.95 ± 0.12

2.49 ± 0.25

2.54 ± 0.26

2.73 ± 0.29

2.12 ± 0.19#

2.72 ± 0.28

2.68 ± 0.22

RVW/BW, mg/g

0.52 ± 0.15

0.94 ± 0.22*

0.65 ± 0.12†

0.55 ± 0.15†‡

0.41 ± 0.13#

0.71 ± 0.18†

0.72 ± 0.22†

LungW/BW, mg/g

4.21 ± 0.38

7.24 ± 0.49*

5.87 ± 0.42*†

5.06 ± 0.38†‡

3.82 ± 0.40#

5.92 ± 0.39*†

5.95 ± 0.38*†

+dp/dt, mmHg/s

7465 ± 318

2281 ± 285*

2983 ± 289*†

3512 ± 259*†‡

3673 ± 298*†‡

2784 ± 315*†

2873 ± 265*†

−dp/dt, mmHg/s

6562 ± 286

1835 ± 258*

2772 ± 302*†

3263 ± 277*†‡

3408 ± 283*†‡

2528 ± 265*†

2595 ± 284*†

Infarct size, %

–

39 ± 2

39 ± 3

38 ± 3

37 ± 3

40 ± 4

40 ± 3

IVS, mm

1.5 ± 0.2

0.5 ± 0.2*

0.8 ± 0.2*

0.8 ± 0.2*

0.8 ± 0.2*

0.6 ± 0.2*

0.8.± 0.2*

LVEDD, mm

6.0 ± 0.2

9.2 ± 0.1*

7.7 ± 0.2*†

7.4 ± 0.2*†‡

7.3 ± 0.3*†‡

7.6 ± 0.2*†

7.8 ± 0.2*†

LVESD, mm

3.8 ± 0.2

7.5 ± 0.2*

6.0 ± 0.2*†

5.6 ± 0.3*†‡

5.5 ± 0.2*†‡

5.9 ± 0.2*†

6.1 ± 0.2*†

LV PW, mm

1.2 ± 0.1

1.8 ± 0.2*

1.7 ± 0.2*

1.7 ± 0.2*

1.8 ± 0.1*

1.8 ± 0.2*

1.9 ± 0.2*

LVEF, %

74.6 ± 5.9

45.8 ± 3.7*

52.9 ± 4.3*†

56.7 ± 4.5*†

57.2 ± 3.8*†

53.5 ± 4.2*†

52.4 ± 3.5*†

  1. Values are mean ± SD
  2. BP n-butylidenephthalide, BW body weight, HR heart rate, IVS interventricular septum, Li lithium, LungW lung weight, LV PW left ventricular posterior wall, LVEDD left ventricular end-diastolic dimension, LVEDP left ventricular end-diastolic pressure, LVEF left ventricular ejection fraction, LVESD left ventricular end-systolic dimension, LVESP left ventricular end-systolic pressure, LVW left ventricular weight, LYLY294002, RVWright ventricular weight
  3. *P < 0.005 compared with sham
  4. †P < 0.05 compared with the infarcted group treated with vehicle
  5. ‡P < 0.05 compared with infarcted groups treated with ADSCs, ADSCs/BP/LY, and ADSCs/BP/S3I-201
  6. #P < 0.05 compared with all infarcted groups
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