Fig. 10 | Laboratory Investigation

Fig. 10

From: Endotoxemia-induced endothelial fibrosis inhibition improves hypotension, tachycardia, multiple organ dysfunction syndrome, cytokine response, oxidative stress, and survival

Fig. 10

GW-induced endothelial fibrosis inhibition decreases the risk of death and mortality in 72-h endotoxemic rats. Contingency analyses (a) and survival (Kaplan–Meier) curves (b) determined in vehicle-treated/saline-treated rats (open circles, N = 8), GW-treated/saline-treated rats (closed squares, N = 8), vehicle-treated/endotoxemic rats (closed circles, N = 8), and GW-treated/endotoxemic rats (open squares, N = 8), after 72 h. In (a), values are expressed as the mean ± 95% confidence interval (CI). *p = 0.0122 (Fisher’s exact test) comparing vehicle-treated/endotoxemic rats versus GW-treated/endotoxemic group. p = 0.0028 when comparing vehicle-treated/endotoxemic rats versus vehicle-treated/saline-treated group. p = 0.0066 when comparing vehicle-treated/endotoxemic rats versus GW-treated/saline-treated group. In (b), *p = 0.0016, §p = 0.0063, ‡p = 0.0275 (log-rank (Mantel–Cox) test) when comparing vehicle-treated/endotoxemic rats compared versus vehicle-treated/saline-treated, GW-treated/saline-treated and GW-treated/endotoxemic rats, respectively

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