Fig. 2
GW-induced endothelial fibrosis inhibition improves hypotension and tachycardia in 72-h endotoxemic rats. Systolic blood pressure (PS) (a) and heart rate (fH) (b) variables in vehicle-treated/saline-treated rats (open circles, N = 8), GW-treated/saline-treated rats (dark gray circles, N = 8), vehicle-treated/endotoxemic rats (closed circles, N = 8), and GW-treated/endotoxemic rats (gray circles, N = 8). GW-788388 was administrated by gavage (5 mg/kg a day) 24 h before and during 72-h endotoxemia. After 1 day of GW-788388 administration, endotoxemia was produced by IP injection of 20 mg/kg LPS. Animals were recorded 12 h in basal condition (basal) and then 24 h with GW-788388 or vehicle administration (GW treatment). Next, animals were challenged with LPS or saline solution for 72 h. Values are expressed as the mean ± SD. *p < 0.05, vehicle-treated/endotoxemic group compared with basal, assessed by ANOVA and Dunnett’s post-test. §p < 0.05, vehicle-treated/endotoxemic group compared with GW-treated/endotoxemic group, assessed by two-way ANOVA and the Bonferroni post-test. ‡p < 0.05, vehicle-treated/endotoxemic group compared with vehicle-treated/saline-treated group, assessed by two-way ANOVA and the Bonferroni post-test. #p < 0.05, vehicle-treated/endotoxemic group compared with GW-treated/saline-treated group, assessed by two-way ANOVA and the Bonferroni post-test. N = 8
