Fig. 3 | Laboratory Investigation

Fig. 3

From: Endotoxemia-induced endothelial fibrosis inhibition improves hypotension, tachycardia, multiple organ dysfunction syndrome, cytokine response, oxidative stress, and survival

Fig. 3

GW-induced endothelial fibrosis inhibition improves MODS in 24-h endotoxemic rats. Alanine aminotransferase (a), aspartate aminotransferase (b), total bilirubin (c), and gamma-glutamyl transferase (d) for the liver function and blood urea nitrogen (e) and creatinine (f) for the kidney function were measured in vehicle-treated/saline-treated rats (open bars, N = 8), vehicle-treated/endotoxemic rats (dashed bars, N = 8), GW-treated/endotoxemic rats (closed bars, N = 8), and GW-treated/saline-treated rats (dark gray bars, N = 8). GW-788388 was administrated by gavage (5 mg/kg a day) 24 h before and during 24-h endotoxemia. Values are expressed as the mean ± SD. *p < 0.05; **p < 0.01, assessed by one-way ANOVA (Kruskal–Wallis) and Dunn’s post-test. N = 8

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