Fig. 4 | Laboratory Investigation

Fig. 4

From: Endotoxemia-induced endothelial fibrosis inhibition improves hypotension, tachycardia, multiple organ dysfunction syndrome, cytokine response, oxidative stress, and survival

Fig. 4

GW-induced endothelial fibrosis inhibition decreases liver and kidney tissue damage in 24-h endotoxemic rats. Representative images of hematoxylin/eosin-stained liver (a–d) and kidney (f–i) sections from vehicle-treated/saline-treated rats (a, f), vehicle-treated/endotoxemic rats (b, g), GW-treated/endotoxemic rats (c, h), and GW-treated/saline-treated rats (d, i), after 24 h. GW-788388 was administrated by gavage (5 mg/kg a day) 24 h before and during 24-h endotoxemia. Images were subjected to blind analysis of tissue liver (e) and kidney (j) damage using the following grading scale for tissue damage: normal = 0, minimal = 1, mild = 2, moderate = 3, marked = 4, and severe = 5. Values are expressed as the mean ± SD. *p < 0.05, **p < 0.01, assessed by one-way ANOVA (Kruskal–Wallis) and Dunn’s post-test. N = 8

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