Fig. 7 | Laboratory Investigation

Fig. 7

From: Endotoxemia-induced endothelial fibrosis inhibition improves hypotension, tachycardia, multiple organ dysfunction syndrome, cytokine response, oxidative stress, and survival

Fig. 7

GW-induced endothelial fibrosis inhibition decreases mRNA and protein expression of TF and vWF in 24-h endotoxemic rats. Tissue factor (TF) and von Willebrand Factor (vWF) were measured in vehicle-treated/saline-treated rats (open bars, N = 6), vehicle-treated/endotoxemic rats (closed bars, N = 6), GW-treated/endotoxemic rats (gray bars, N = 6), and GW-treated/saline-treated rats (dark gray bars, N = 6). GW-788388 was administrated by gavage (5 mg/kg a day) 24 h before and during 24-h endotoxemia. TF (a) and vWF (b) mRNA levels were measured. Representative images (c, d) and densitometric analyses (e, f) from western blot experiments performed for the detection of TF (c, e) and vWF (d, f) protein levels. Values are expressed as the mean ± SD. **p < 0.01, assessed by one-way ANOVA (Kruskal–Wallis) and Dunn’s post-test. N = 6

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